Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity
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چکیده
منابع مشابه
Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensis
The present work aimed to analyze the alkaloid content of the ethanolic extract of Tabernaemontana catharinensis (Apocynaceae family) and its fractions as well as to evaluate their antioxidant and anticholinesterasic activities. The analyses of the ethanolic extract of T. catharinensis by mass spectrometry allowed identifying the presence of the alkaloids 16-epi-affinine, coronaridine-hydroxyin...
متن کاملEXTRACTION AND ISOLATION OF INDOLE ALKALOIDS FROM Tabernaemontana catharinensis: TECHNICAL AND ECONOMICAL ANALYSIS
Leishmaniasis is a parasitic infection that is considered worldwide one of the most important public health problem, affecting more than 12 million people with an estimated number of 2 million new cases occurring annually. Among the compounds isolated from Tabernaemontana catharinensis, coronaridine and voacangine are the indole alkaloids which have antileishmanial activity. In this work, the t...
متن کاملSUPERCRITICAL EXTRACTION OF INDOLE ALKALOIDS FROM Tabernaemontana catharinensis: AN EVALUATION OF THE COSOLVENT ON THE EXTRACT COMPOSITIONS
Tabernaemontana catharinensis is a tree rich in indole alkaloids, such as coronaridine and voacangine that have antileishmanial activity. SFE from T.catharinensis using CO2 + 5.1% (m/m) of cosolvent (ethanol, isopropyl alcohol, methanol, water and their mixtures) was studied. The global yields and the compositions of extracts were determined. The data were taken at 250 bar, 45oC, and total solv...
متن کاملChemical constituents from the root bark of Ozoroa insignis
The roots of Ozoroa insignis Del. (Heeria insignis Del.) (Anacardiaceae) are used as a remedy for diarrhea, venereal diseases, tapeworm and hookworm, schistosomiasis, kidney trouble, migraine, and malaria (Liu and Abreu, 2007). In previous biological screening of O. insignis extracts, anthelmintic effect, cytotoxic activity, and topoisomerase inhibition were reported (Liu and Abreu, 2006a). The...
متن کاملCytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)
Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents. Tabernaemontana catharinensis is a medicinal plant that produces alkaloids with expressive antitumor acti...
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ژورنال
عنوان ژورنال: Química Nova
سال: 2008
ISSN: 0100-4042
DOI: 10.1590/s0100-40422008000100004